From: NYT Research
The full results from a trial in Thailand showed that the
vaccine’s protective effect might be even
weaker than researchers first admitted.
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THAILAND: Success of AIDS Vaccine Trial Is at Issue
The AIDS vaccine tested in a recent trial in Thailand is not as
promising as it appears at first blush, according to reports in the
Wall Street Journal and on the Web site of the journal Science. The
second look is based on reports by anonymous AIDS researchers who
were given confidential briefings on the study before a conference
in Paris in late October. The original report said the vaccine is
31 percent better than a placebo in preventing AIDS, with a 4
percent chance that the difference is merely random. In fact, the
new published accounts contend, the vaccine might be 26 percent
better than nothing. At issue is a question about the
study’s methodology - how to characterize the
16,396 Thais who participated at some point in the study. Critics
say that if the analysis were limited ...
THAILAND: AIDS Vaccine Is of Modest Help, Fuller Research Says
A more extensive analysis of data from a Thailand-based trial
indicates that an experimental AIDS vaccine may have been less
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announced that the vaccinations - which combined two vaccines
previously shown to be ineffective when given separately - had
lowered HIV infection risk by about 31 percent. Calculations
indicated a 4 percent likelihood the effect was due to chance -
clearing the 5 percent chance threshold applied in drug and vaccine
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participants. The initial results were based on a
“modified intent to treat†analysis
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AIDS vaccines stop working after a few months, shocked researchers discover
(NaturalNews) An experimental new AIDS vaccine is proving to be
effective for only a very short time, according to researchers who
have been finding it difficult to explain whether or not the drug
is actually useful. Dr. Nelson Michael, a colonel at the Walter
Reed Army Research Institute of Research in Maryland, and his team
observed only a minor, temporal benefit in patients who took the
vaccine, followed by a decline in efficacy.The experimental vaccine
is a combination of Sanofi-Pasteur's ALVAC canarypox/HIV vaccine
and VaxGen's AIDSVAX. After AIDSVAX was found to be ineffective in
2003, researchers decided to combine it with ALVAC to see if that
combination would work. Early results appeared to show that the
vaccine reduced the risk of becoming infected with AIDS by 31
percent. Howeve...
UNITED STATES: Brief Shocks May Deliver AIDS Vaccines Better - Study
Delivering electrical pulses along with an experimental AIDS
vaccine elicited a better immune response in volunteers than
administering the injection alone, researchers said Thursday at the
AIDS Vaccine 2009 conference in Paris. Employing a technique called
electroporation, US researchers used a device that looks like a
pistol to inject a weakened DNA-based vaccine as well as three
brief electric shocks. “With a brief pulse of
electricity, our cell membrane temporarily opens up and allows a
lot more of the DNA to get inside,†said Sandhya Vasan
of the Aaron Diamond AIDS Research Center in New York.
“The reason why DNA vaccines by themselves
don’t trigger a powerful immune response is
because most of [the DNA] does not get inside our
cells.†When injected alone, the vaccine prod...
